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KMID : 0378019890320050111
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New Medical Journal
1989 Volume.32 No. 5 p.111 ~ p.116
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Comparative analgestic and safety study of Ketorolac tromethamine and Tramadol
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Abstract
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Safer and more effective intramuscular administered substitutes for narcotic analgesics are needed for relief of pain of :various etiologies. This study was aimed at evaluating the relative analgesic efficacy and safety of Ketorolac tromethamine 10mg compared to tramadol 50mg in the treatment of acute orthopedic postoperative pain.
The results were as follows
1. Early terminations of the study for no pain experienced were 37% in the ketorolac group and 20% in tramadol group, and for inadequate pain. relief were 10% in ketorolac group and 13% in tramadol group.
2. Summed pain intensity differences (SPID) score was 5.24 in ketorolac group and 2.42 in tramadol group.
3. Total pain relief (TOTPAR) score was 10.26 in ketorolac group and 6.67 in tramadol group. 4. Mean action duration was 7.0 hours in ketorolac group and 6.2 hours in tramadol group.
5. Overall opinions on the study medication as an analgesic agents, for the patient pain relief score were 2.37 in ketorolac group and 1.32 in tramadol group, and for the investigator, 2.1 in ketorolac group and 1.27 in tramadol group.
6. The rates of adverse events were 60% in ketorolac group and 66% in tramadol group, and most of the adverse events were mild. There was no early termination for adverse even.
7. Our study demonstrates that ketorolac tromethamine is a safer and more effective analgesic when administered intramuscularly with only minimal side effects, and a significantly longer duration of action than tramadol.
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